Pharmaceutical Organic Chemistry 2

Unit 1

Benzene and its derivatives

Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule

Reactions of benzene - nitration, sulphonation, halogenation reactivity, Friedel crafts alkylation- reactivity, limitations, Friedel crafts acylation.

Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction

Structure and uses of DDT, Saccharin, BHC and Chloramine

Open Unit 1​​​​​​

Unit 2

Phenol

Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols

Aromatic Amines

Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts

Aromatic Acids

Acidity, effect of substituents on acidity and important reactions of benzoic acid.

Open Unit 2

Unit 3

Fats and Oils

• Fatty acids - reactions.
• Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils.
• Analytical constants - Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value - significance and principle involved in their determination.

Open Unit 3

Unit 4

Polynuclear hydrocarbons:

• Synthesis, reactions
• Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives

Open Unit 4

Unit 5

Cyclo alkanes

Stabilities - Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only

Open Unit 5