Unit 1
Controlled drug delivery systems:
Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations
Polymers:
Introduction, classification, properties, advantages and application of polymers in formulation of controlled release drug delivery
Unit 2
Microencapsulation:
Definition, advantages and disadvantages, microspheres/microcapsules, microparticles, methods of microencapsulation, applications
Mucosal Drug Delivery system:
Introduction, Principles of bio adhesion /Muc adhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems
Implantable Drug Delivery Systems:
Introduction, advantages and disadvantages, concept of implantsand osmotic pump
Unit 3
Transdermal Drug Delivery Systems:
Introduction, Permeation through skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches
Gastroretentive drug delivery systems:
Introduction, advantages, disadvantages, approaches for GRDDS - Floating, high density systems, inflatable and gastroadhesive systems and their applications
Nasopulmonary drug delivery system:
Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers
Unit 4
Targeted drug Delivery:
Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications
Unit 5
Ocular Drug Delivery Systems:
Introduction, intra ocular barriers and methods to overcome - Preliminary study, ocular formulations and ousters
Intrauterine Drug Delivery Systems:
Introduction, advantages and disadvantages, development of intra uterine devices (IUDs) and applications